Recent research and neuroscientists has provided strong evidence supporting the use of non-invasive vagus nerve stimulation (nVNS) for treating mental disorders in pediatric and prenatal groups. Interestingly, it is well-documented that the use of antidepressants during pregnancy can lead to complications such as low birth weight and preterm delivery due to their ability to cross the placenta. In contrast, one study demonstrated that VNS was an effective treatment for depression during pregnancy, with no adverse outcomes for either the mother or the fetus. [1] On top of that, another study reported significant improvements in well-being and quality of life among children treated with nVNS. This is particularly impactful in the current landscape of depression treatment, which is limited in young people due to the side effects and potential harm of pharmaceutical options to cognitive development. [2]
This growing body of research underscores the potential of nVNS as a safe and effective solution not only for vulnerable groups but also for the general adult population. By successfully treating conditions in these sensitive groups, we also glean insights that can be applied to broader adult care. Consider the well-known detrimental effects of substances like alcohol, drugs, and poor diets, which are especially harmful during pregnancy and childhood, but also adversely affect adults. Thanks to technology and scientific research, who are taking significant strides in shifting outdated mindsets and addressing health issues at their core and in more humane ways, rather than merely managing symptoms and producing further unpleasant effects.
Vagus nerve stimulation, such as with NUROSYM technology, sends mild electrical stimulation through the skin to the vagus nerve. This helps to activate the nerve, which in turn supports the body in shifting from the ‘fight or flight’ state to the ‘rest and digest’ state. Rather than relaxing the nerve, the stimulation encourages the vagus nerve to enhance its function, thereby promoting a calming effect on the body.
https://friona.me/wp-content/uploads/2024/04/FRIONA-Main-Logo-300x81.png00frionahttps://friona.me/wp-content/uploads/2024/04/FRIONA-Main-Logo-300x81.pngfriona2024-12-15 18:57:132024-12-15 18:57:16Thanks to technology, that shifts medical healthcare in a more humane way
Neuroplasticity is a powerful mechanism in our brains that functions like a prediction machine, shaping how we react in specific situations. Our mix of personality traits, built through life experiences, plays a significant role in this process. But can people change? Many of us have encountered situations where we think, “That’s just their personality, they won’t change,” or find ourselves repeating the same unhelpful behaviors, feeling it’s beyond our control to change these patterns. Neuroscience, however, strongly disagrees with the notion of a fixed personality. As long as our brain neurons can change their paths, reconnect, and grow, we have the potential to change and become whoever we want, depending on our experiences.
That said, it’s not as easy with aging. After the age of 25, our brain’s development starts to slow down. For instance, learning a new language in your 40s becomes a challenging task. Cognitive reserve, the brain’s resilience to age-related changes, is built up through a lifetime of learning and experiences, helping to delay the onset of cognitive impairments. [1]Enhanced neuroplasticity is vital for aging individuals as it enables the brain to adapt to new experiences and learn new skills, thus maintaining cognitive health. [2] It also plays a crucial role in recovery from brain injuries, such as strokes, which are more common in older adults. Moreover, improved neuroplasticity can help combat the effects of neurodegenerative diseases like Alzheimer’s by maintaining neural connections and cognitive functions. [3]
These reasons alone underscore the importance of neuroplasticity. Simply put, it’s essential for us to enjoy our daily lives, make things easier, and feel happiness. So, how can we enhance our brain’s neuroplasticity? While trauma can drastically change the brain, there are positive ways to promote neuroplasticity, such as physical exercises, continuous learning, and non-invasive vagus nerve stimulation (VNS).
Non-invasive vagus nerve stimulation (VNS) has emerged as a promising therapy to enhance neuroplasticity. VNS works by stimulating the vagus nerve, which in turn increases levels of brain-derived neurotrophic factor (BDNF). BDNF is a protein that plays a critical role in brain health by supporting the survival, growth, and differentiation of neurons and synapses. It enhances synaptic plasticity, which is essential for learning and memory. [4] By increasing BDNF levels, VNS helps strengthen the connections between neurons, making it easier for the brain to form new neural pathways.
Studies have shown that VNS can improve cognitive functions such as working memory and attention, which are vital for maintaining cognitive health in adults. [5] For example, an adult taking up a musical instrument can benefit from enhanced neuroplasticity, making the learning process more effective and enjoyable. By promoting neuroplasticity, VNS offers a promising avenue for improving the quality of life and cognitive health in adults.
https://friona.me/wp-content/uploads/2024/03/nurosym_1.png539503frionahttps://friona.me/wp-content/uploads/2024/04/FRIONA-Main-Logo-300x81.pngfriona2024-12-15 18:49:392024-12-15 18:49:42PEOPLE CAN CHANGE – THE POWER OF NEUROPLASTICITY
Indications & contraindications. The following health conditions & syndromes have been linked to autonomic nervous system imbalance or Vagus Nerve Impairment: Chronic Fatigue Syndrome (CFS)/ Myalgic encephalomyelitis (ME) / Brain fog Irritable Bowel Syndrome (IBS) Anxiety and Stress related conditions Migraines Inflammatory conditions Insomnia Depression / Major Depressive Disorder (MDD) Long-Covid Postural Orthostatic Tachycardia Syndrome (POTS) Post-Viral Syndrome Autoimmune conditions (Rheumatoid Arthritis, Crohn’s Disease) Fibromyalgia Epilepsy Tinnitus Heart Failure Atrial Fibrillation What’s more, some research data suggests Nurosym also improves learning and short-term memory and cognition. Nurosym also has been shown to promote relaxation, mood, sleep, healthy digestion, increased HRV, as well as to alleviate symptoms of stress, burnout, adrenal fatigue. Research is also investigating the impact of neuromodulation on athletic performance, muscle recovery, obesity, alcoholism and more. If you’re not sure if Nurosym is for you, take our Vagus Nerve Impairment Assessment consult with your doctor or contact our medical support by clicking the Support icon at the bottom right of the page.
How Nurosym works. Nurosym sends patented electrical impulses to the brain via the Vagus Nerve, which leads to:
Activation of parasympathetic nervous system & Improved HRV a) Parasympathetic nervous systemis the body’s internal relaxation & self-repair mechanism. Vagus Nerve is its main component that connects to most organs and mediates signals to rest & heal. Heart Rate Variability (HRV) is an indicator of Vagus Nerve activity. Improving parameters of HRV indicate targeted stimulation of the vagus nerve and activation of specific self-repair mechanisms of body & mind. In clinical trials, one hour sessions of Nurosym favourably altered all three parameters of Heart Rate Variability (HRV), when compared to placebo.
Figure (a) shows High Frequence HRV is significantly increased (‘p=0.001). Figure (b) shows Low Frequency HRV is significantly decreased (‘P=0.001). Figure (c) shows the ratio of LF to HF is significantly decreased (*p=0.002). Source: Geng, D., Liu, X., Wang, Y., & Wang, J. (2022). The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people. b) Health Implications: Stress resilience Depression, Anxiety Insomnia & other sleep problems Cardiovascular health Athletic recovery Ageing & Longevity Reduced Inflammation: Inflammation throughout the body and brain contributes to diseases development, progression, ageing and mental health problems. Cytokines are the main biomarkers (measures) of inflammation in the body. In a randomised controlled trial, inflammatory cytokines were significantly lower in the group that received Nurosym neuromodulation compared to the placebo group at the end of 3 months.
The figure presents the changes in two inflammatory biomarkers: Tumor necrosis factor (TNF)‐α and Interleukin (IL)‐8. Source: Stavrakis, S., Elkholey, K., Morris, L., Niewiadomska, M., Asad, Z. U. A., & Humphrey, M. B. (2022). Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial. Journal of the American Heart Association
1.Improved cognitive functions Vagus Nerve Impairment, low parasympathethic activity & inflammation are often associated with cognitive problems, such as brain fog, fatigue, depression. Nurosym has been shown to provide improvements on a few biomarkers of cognition & mood. 2. Improved memory Nurosym improves memory on learning tasks in comparison to placebo. (A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.
Source: Thakkar, V., Richardson, Z. A., Dang, A., & Centanni, T. (2021) Improvement of memory-based reading recall using transcutaneous auricular vagus nerve stimulation.
3. Better learning Nurosym paired with training improved performance on speed and decoding learning task measures in comparison to placebo.
Nurosym neuromodulation significantly improved speed on the Automaticity learning task compared to controls. Nurosym neuromodulation also significantly improved percent correct on the Decoding learning task as compared to controls. ∗p < 0.05. Source: Thakkar, V. J., Engelhart, A. S., Khodaparast, N., Abadzi, H., & Centanni, T. M. (2020). Transcutaneous auricular vagus nerve stimulation enhances learning of novel letter-sound relationships in adults. Brain Stimulation 4. Health implications: Brain Fog Depression Chronic Fatigue Syndrome (ME/CFS) Long-Covid Alzheimer’s & Dementia Ageing & Longevity Cognitive enhancement
Science & Clinical Evidence Does Nurosym work? Yes, Clinical evidence supports it What can Nurosym do for me? Clinical research has shown Nurosym provides the following benefits confirmed by thousands of patients worldwide: Reduced brain fog Improved memory & cognition Reversed mechanisms causing fatigue Reduced fight or flight response and stress Reduced Depression/Anxiety Improved mood Improved Heart Rate Variability (HRV) Reduced post-viral symptoms Improved sleep Decreased inflammation & oxidative stress Reduced gut symptoms
Scientific method & research principles Nurosym has partnered with 60+ research institutions, including UCLA and Harvard, to conduct clinical trials to validate the health benefits of Nurosym. Our research is founded on these principles Parasym’s studies are led by independent university experts, with no financial ties to us, unless explicitly mentioned. Our research is externally funded, ensuring unbiased and genuine results. We value transparency: All our trial findings (positive or otherwise) are open and accessible to everyone. We collaborate with distinguished physicians and scientists, ensuring the pinnacle of research quality. At Parasym, we adhere to the highest scientific standards, consistently achieving significant and trustworthy results in the most stringent tests. A large part of our clinical evidence comes from Randomised Placebo-controlled Clinical Trials, which are considered the highest standard of evidence.
Clinical Evidence
Reduced fatigue & increased energy
Reduced Long Covid Symptom Intensity including Brain Fog & Fatigue
Reduced depression & improved mood
Reduced Postural Orthostatic Tachycardia
Improved blood circulation
Certifications & Safety Yes, Nurosym is considered safe when used as intended. Nurosym is a certified medical device (CE) in Europe. It has also received FDA Non-Significant Risk Designation in multiple studies in the US. This means: It has been audited by medical regulators It is based on rigorous scientific evidence The benefits outweighs the risks It has demonstrated clinical efficacy It has strict quality management systems Be sure to read the important safety information before use. Nurosym has been evaluated in randomised placebo controlled clinical trials and now used widely with over 2M treatment sessions and 0 serious adverse events have been reported. Its safety has been confirmed in multiple clinical studies.
How to use Nurosym Watch Dr Denef explain how to use Nurosym:
How to use Nurosym in a few steps:
Apply a bit of moisture on the tragus.
Wear the earpiece correctly on your left tragus, the cable should go over and behind your ear to keep the electrodes in place.
Turn on Nurosym
Slowly increase energy level until you feel a light tingling sensation in your ear.
Notice how pleasant the sensation of neuromodulation feels. This is a signal that the current is flowing and that your parasympathetic nervous system is activated.
Sit or lie down with the device or perform daily activities while Nurosym works to strengthen your parasympathetic nervous system, decrease inflammation, oxidative stress and activate neuroplasticity to help you feel better.
Notice the sensations of calmness, relaxation, decreased stress, improved mood, more energy flowing into your body.
If you feel the sensation intensifies over time or you stop feeling it, adjust the energy level until you feel a light pleasant tingling sensation again.
Continue using Nurosym every day for 30-60 mins a day, preferably in the morning or split between morning after waking up and evening before sleep and enjoy better health & mood.
Why Nurosym Gold standard in clinical research Nurosym is a certified medical device, with over $10M deployed in clinical trials, 60+ partner research organisations including Harvard, UCLU, 30+ published papers in leading journals covering our exciting and clinically significant results. This is why Nurosym is the leading non-invasive vagal neuromodulation system used in clinical neuromodulation research and now widely adopted. Certified medical device with confirmed safety Exposing your nervous system and brain to untested electrical currents can put you at risk of a permanent damage to the brainstem and vagal nerve fibres, worsening your symptoms. Never use or suggest using DIY electrical current devices on your nervous system. Ensuring safety and efficacy requires extensive clinical studies that cost millions of dollars. This is why few Neuromodulation devices have been certified by health regulatory bodies as safe and effective. Beware of websites claiming to deliver benefits from uncertified treatments that present online reviews instead of clinical evidence. Carefully verify if a treatment you’re evaluating is registered as a medical device, which certifies it is safe and effective to use. When considering any health intervention, be sure to evaluate the status of certification, clinical evidence, warnings and seek advice of trusted health care professionals. Nurosym is one of a few registered neuromodulation based medical devices with safety confirmed by regulatory bodies in EU in Randomised Placebo Controlled Studies. Nurosym has a CE Mark in the EU and has been awarded FDA Non-Significant Risk Designation, which both confirm safety of our device. Proven target activity In addition to safety, it is crucial to consider efficacy of various devices. The fact that a device is delivering a safe electrical current is not enough. It also needs to demonstrate that it indeed stimulates the right nerves and activates them. Triggering nerve action potential to fire requires precise waveform, frequency, wavelength and amplitude of electrical signal, as well as a specific stimulation site on the body closest to a particular branch of the vagus nerve. Without clinical data, we cannot know if a device is 1)actually stimulating the right neural pathways 2)not stimulating unintended neural pathway. Nurosym is demonstrated in clinical studies to stimulate the brainstem via the vagus nerve. Our patented waveform that exerts these effects has been developed over 8 years of laborious research with a total cost of over $10M. Efficacy confirmed in Randomised Placebo Controlled Studies Many devices on the market claim benefits when combined with other practices such as meditation or breathing, which independently provide benefits such as relaxation, anxiety, mood, stress, sleep. This fact makes it hard to discern whether claimed benefits are due to the device itself or the additional practice. What’s more placebo effect is a strong influencer on benefits of numerous devices. Only randomised placebo controlled clinical studies can demonstrate whether a device benefit is independent of the placebo effect. Make sure to verify quality of evidence provided by the manufacturer. Nurosym has demonstrated benefits independent of other practices in a number of Randomised Placebo Controlled Studies.
Medical disclaimer. Important safety information Nurosym might not be right for you. Before ordering, be sure to read about intended use, warnings, precautions and contraindications. Consult with your doctor before using any medical intervention. If you don’t have a doctor and would like to consult our team, contact us.
