Nurosym
Indications & contraindications. The following health conditions & syndromes have been linked to autonomic nervous system imbalance or Vagus Nerve Impairment:
Chronic Fatigue Syndrome (CFS)/ Myalgic encephalomyelitis (ME) / Brain fog
Irritable Bowel Syndrome (IBS)
Anxiety and Stress related conditions
Migraines
Inflammatory conditions
Insomnia
Depression / Major Depressive Disorder (MDD)
Long-Covid
Postural Orthostatic Tachycardia Syndrome (POTS)
Post-Viral Syndrome
Autoimmune conditions (Rheumatoid Arthritis, Crohn’s Disease)
Fibromyalgia
Epilepsy
Tinnitus
Heart Failure
Atrial Fibrillation
What’s more, some research data suggests Nurosym also improves learning and short-term memory and cognition.
Nurosym also has been shown to promote relaxation, mood, sleep, healthy digestion, increased HRV, as well as to alleviate symptoms of stress, burnout, adrenal fatigue.
Research is also investigating the impact of neuromodulation on athletic performance, muscle recovery, obesity, alcoholism and more.
If you’re not sure if Nurosym is for you, take our Vagus Nerve Impairment Assessment
consult with your doctor or contact our medical support by clicking the Support icon at the bottom right of the page.
How Nurosym works.
Nurosym sends patented electrical impulses to the brain via the Vagus Nerve, which leads to:
- Activation of parasympathetic nervous system & Improved HRV
a) Parasympathetic nervous system is the body’s internal relaxation & self-repair mechanism. Vagus Nerve is its main component that connects to most organs and mediates signals to rest & heal. Heart Rate Variability (HRV) is an indicator of Vagus Nerve activity. Improving parameters of HRV indicate targeted stimulation of the vagus nerve and activation of specific self-repair mechanisms of body & mind. In clinical trials, one hour sessions of Nurosym favourably altered all three parameters of Heart Rate Variability (HRV), when compared to placebo.
Figure (a) shows High Frequence HRV is significantly increased (‘p=0.001). Figure (b) shows Low Frequency HRV is significantly decreased (‘P=0.001). Figure (c) shows the ratio of LF to HF is significantly decreased (*p=0.002).
Source:
Geng, D., Liu, X., Wang, Y., & Wang, J. (2022). The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people.
b) Health Implications:
Stress resilience
Depression, Anxiety
Insomnia & other sleep problems
Cardiovascular health
Athletic recovery
Ageing & Longevity
Reduced Inflammation:
Inflammation throughout the body and brain contributes to diseases development, progression, ageing and mental health problems.
Cytokines are the main biomarkers (measures) of inflammation in the body.
In a randomised controlled trial, inflammatory cytokines were significantly lower in the group that received Nurosym neuromodulation compared to the placebo group at the end of 3 months.
- The figure presents the changes in two inflammatory biomarkers: Tumor necrosis factor (TNF)‐α and Interleukin (IL)‐8. Source:
Stavrakis, S., Elkholey, K., Morris, L., Niewiadomska, M., Asad, Z. U. A., & Humphrey, M. B. (2022). Neuromodulation of Inflammation to Treat Heart Failure With Preserved Ejection Fraction: A Pilot Randomized Clinical Trial. Journal of the American Heart Association - Health implications:
- Cardiovascular health (AF, HF, Hypertension)
- Ageing & Longevity
- Muscle pain
- Chronic pain
- Mental health conditions
- Autoimmune conditions (e.g. Rheumatoid Arthritis, Crohn’s Disease)
- Post-viral syndromes (Long-Covid, Lyme Disease)
- IBS, GERD & other GI symptoms
1. Improved cognitive functions
Vagus Nerve Impairment, low parasympathethic activity & inflammation are often associated with cognitive problems, such as brain fog, fatigue, depression.
Nurosym has been shown to provide improvements on a few biomarkers of cognition & mood.
2. Improved memory
Nurosym improves memory on learning tasks in comparison to placebo.
(A) There was a significant benefit of Nurosym neuromodulation compared to placebo across all test questions. (B) This effect was driven by a significant benefit of Nurosym neuromodulation on memory questions.
Source: Thakkar, V., Richardson, Z. A., Dang, A., & Centanni, T. (2021) Improvement of memory-based reading recall using transcutaneous auricular vagus nerve stimulation.
3. Better learning
Nurosym paired with training improved performance on speed and decoding learning task measures in comparison to placebo.
Nurosym neuromodulation significantly improved speed on the Automaticity learning task compared to controls. Nurosym neuromodulation also significantly improved percent correct on the Decoding learning task as compared to controls. ∗p < 0.05.
Source: Thakkar, V. J., Engelhart, A. S., Khodaparast, N., Abadzi, H., & Centanni, T. M. (2020). Transcutaneous auricular vagus nerve stimulation enhances learning of novel letter-sound relationships in adults. Brain Stimulation
4. Health implications:
Brain Fog
Depression
Chronic Fatigue Syndrome (ME/CFS)
Long-Covid
Alzheimer’s & Dementia
Ageing & Longevity
Cognitive enhancement
Science & Clinical Evidence
Does Nurosym work?
Yes, Clinical evidence supports it
What can Nurosym do for me?
Clinical research has shown Nurosym provides the following benefits confirmed by thousands of patients worldwide:
Reduced brain fog
Improved memory & cognition
Reversed mechanisms causing fatigue
Reduced fight or flight response and stress
Reduced Depression/Anxiety
Improved mood
Improved Heart Rate Variability (HRV)
Reduced post-viral symptoms
Improved sleep
Decreased inflammation & oxidative stress
Reduced gut symptoms
Scientific method & research principles
Nurosym has partnered with 60+ research institutions, including UCLA and Harvard, to conduct clinical trials to validate the health benefits of Nurosym.
Our research is founded on these principles
Parasym’s studies are led by independent university experts, with no financial ties to us, unless explicitly mentioned.
Our research is externally funded, ensuring unbiased and genuine results.
We value transparency: All our trial findings (positive or otherwise) are open and accessible to everyone.
We collaborate with distinguished physicians and scientists, ensuring the pinnacle of research quality.
At Parasym, we adhere to the highest scientific standards, consistently achieving significant and trustworthy results in the most stringent tests. A large part of our clinical evidence comes from Randomised Placebo-controlled Clinical Trials, which are considered the highest standard of evidence.
- Clinical Evidence
- Reduced fatigue & increased energy
- Reduced Long Covid Symptom Intensity including Brain Fog & Fatigue
- Reduced depression & improved mood
- Reduced Postural Orthostatic Tachycardia
- Improved blood circulation
Certifications & Safety
Yes, Nurosym is considered safe when used as intended.
Nurosym is a certified medical device (CE) in Europe. It has also received FDA Non-Significant Risk Designation in multiple studies in the US.
This means:
It has been audited by medical regulators
It is based on rigorous scientific evidence
The benefits outweighs the risks
It has demonstrated clinical efficacy
It has strict quality management systems
Be sure to read the important safety information before use.
Nurosym has been evaluated in randomised placebo controlled clinical trials and now used widely with over 2M treatment sessions and 0 serious adverse events have been reported.
Its safety has been confirmed in multiple clinical studies.
How to use Nurosym
Watch Dr Denef explain how to use Nurosym:
How to use Nurosym in a few steps:
- Apply a bit of moisture on the tragus.
- Wear the earpiece correctly on your left tragus, the cable should go over and behind your ear to keep the electrodes in place.
- Turn on Nurosym
- Slowly increase energy level until you feel a light tingling sensation in your ear.
- Notice how pleasant the sensation of neuromodulation feels. This is a signal that the current is flowing and that your parasympathetic nervous system is activated.
- Sit or lie down with the device or perform daily activities while Nurosym works to strengthen your parasympathetic nervous system, decrease inflammation, oxidative stress and activate neuroplasticity to help you feel better.
- Notice the sensations of calmness, relaxation, decreased stress, improved mood, more energy flowing into your body.
- If you feel the sensation intensifies over time or you stop feeling it, adjust the energy level until you feel a light pleasant tingling sensation again.
- Continue using Nurosym every day for 30-60 mins a day, preferably in the morning or split between morning after waking up and evening before sleep and enjoy better health & mood.
Why Nurosym
Gold standard in clinical research
Nurosym is a certified medical device, with over $10M deployed in clinical trials, 60+ partner research organisations including Harvard, UCLU, 30+ published papers in leading journals covering our exciting and clinically significant results.
This is why Nurosym is the leading non-invasive vagal neuromodulation system used in clinical neuromodulation research and now widely adopted.
Certified medical device with confirmed safety
Exposing your nervous system and brain to untested electrical currents can put you at risk of a permanent damage to the brainstem and vagal nerve fibres, worsening your symptoms. Never use or suggest using DIY electrical current devices on your nervous system.
Ensuring safety and efficacy requires extensive clinical studies that cost millions of dollars. This is why few Neuromodulation devices have been certified by health regulatory bodies as safe and effective.
Beware of websites claiming to deliver benefits from uncertified treatments that present online reviews instead of clinical evidence. Carefully verify if a treatment you’re evaluating is registered as a medical device, which certifies it is safe and effective to use.
When considering any health intervention, be sure to evaluate the status of certification, clinical evidence, warnings and seek advice of trusted health care professionals.
Nurosym is one of a few registered neuromodulation based medical devices with safety confirmed by regulatory bodies in EU in Randomised Placebo Controlled Studies.
Nurosym has a CE Mark in the EU and has been awarded FDA Non-Significant Risk Designation, which both confirm safety of our device.
Proven target activity
In addition to safety, it is crucial to consider efficacy of various devices.
The fact that a device is delivering a safe electrical current is not enough.
It also needs to demonstrate that it indeed stimulates the right nerves and activates them. Triggering nerve action potential to fire requires precise waveform, frequency, wavelength and amplitude of electrical signal, as well as a specific stimulation site on the body closest to a particular branch of the vagus nerve.
Without clinical data, we cannot know if a device is 1)actually stimulating the right neural pathways 2)not stimulating unintended neural pathway.
Nurosym is demonstrated in clinical studies to stimulate the brainstem via the vagus nerve. Our patented waveform that exerts these effects has been developed over 8 years of laborious research with a total cost of over $10M.
Efficacy confirmed in Randomised Placebo Controlled Studies
Many devices on the market claim benefits when combined with other practices such as meditation or breathing, which independently provide benefits such as relaxation, anxiety, mood, stress, sleep. This fact makes it hard to discern whether claimed benefits are due to the device itself or the additional practice.
What’s more placebo effect is a strong influencer on benefits of numerous devices. Only randomised placebo controlled clinical studies can demonstrate whether a device benefit is independent of the placebo effect. Make sure to verify quality of evidence provided by the manufacturer.
Nurosym has demonstrated benefits independent of other practices in a number of Randomised Placebo Controlled Studies.
Medical disclaimer.
Important safety information
Nurosym might not be right for you. Before ordering, be sure to read about intended use, warnings, precautions and contraindications.
Consult with your doctor before using any medical intervention.
If you don’t have a doctor and would like to consult our team, contact us.